GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs1930961 | 1 | rs6004672 | chr22:25881013 | CRYBB2 | chr22:25615612-25627836:+ | 0.91 | 9.5 | 2.28E-19 | Bipolar disorder with mood-incongruent psychosis |
| BLCA | cis | rs1930961 | 1 | rs6004673 | chr22:25885353 | CRYBB2 | chr22:25615612-25627836:+ | 0.8 | 8.38 | 1.02E-15 | Bipolar disorder with mood-incongruent psychosis |
| BLCA | cis | rs60111824 | 1 | rs60111824 | chr7:6774135 | C7orf28B | chr7:6838572-6865861:- | -0.55 | -4.67 | 4.18E-6 | Ejection fraction in Tripanosoma cruzi seropositivity |
| BLCA | cis | rs601338 | 1 | rs601338 | chr19:49206674 | FUT2 | chr19:49199228-49209190:+ | -0.24 | -4.01 | 7.33E-5 | Blood metabolite levels;Blood metabolite ratios |
| BLCA | cis | rs7714584 | 1 | rs60134818 | chr5:150261043 | LOC134466 | chr5:150310000-150326146:- | 0.46 | 6.06 | 3.18E-9 | Crohn's disease |
| BLCA | cis | rs60843830 | 1 | rs60149603 | chr2:285421 | SH3YL1 | chr2:218138-264810:- | -0.46 | -11.73 | 2.24E-27 | Spherical equivalent (joint main effects and education interaction) |
| BLCA | cis | rs1499614 | 1 | rs60326618 | chr7:66166358 | CCT6P1 | chr7:65216092-65228661:+ | 0.35 | 4.69 | 3.85E-6 | Gout |
| BLCA | cis | rs17108533 | 1 | rs60417730 | chr14:71228992 | MAP3K9 | chr14:71194856-71275888:- | 0.43 | 4.54 | 7.39E-6 | Response to antipsychotic treatment in schizophrenia (reasoning) |
| BLCA | cis | rs60843830 | 1 | rs60484953 | chr2:221560 | SH3YL1 | chr2:218138-264810:- | -0.45 | -11.8 | 1.32E-27 | Spherical equivalent (joint main effects and education interaction) |
| BLCA | cis | rs6051080 | 1 | rs6051080 | chr20:25975674 | FAM182B | chr20:25744102-25848786:- | 0.46 | 7.42 | 7.55E-13 | Colorectal or endometrial cancer |
| BLCA | cis | rs965469 | 1 | rs6051713 | chr20:3265779 | ITPA | chr20:3190056-3204504:+ | 0.25 | 3.82 | 0.000154 | IFN-related cytopenia |
| BLCA | cis | rs454422 | 1 | rs6053815 | chr20:5970438 | MCM8 | chr20:5931298-5975829:+ | -0.19 | -4.16 | 3.91E-5 | HIV-1 viral setpoint |
| BLCA | cis | rs454422 | 1 | rs6053816 | chr20:5970750 | MCM8 | chr20:5931298-5975829:+ | -0.21 | -4.46 | 1.07E-5 | HIV-1 viral setpoint |
| BLCA | cis | rs6087771 | 1 | rs6058352 | chr20:30269179 | COX4I2 | chr20:30225691-30232800:+ | 0.21 | 4.43 | 1.22E-5 | Subcortical brain region volumes |
| BLCA | cis | rs6087771 | 1 | rs6058465 | chr20:30397691 | COX4I2 | chr20:30225691-30232800:+ | 0.2 | 4.25 | 2.68E-5 | Subcortical brain region volumes |